Alpha-fetoprotein Testing (AFP)


As your baby grows, it produces AFP. This protein is found in increasing amounts in the amniotic fluid. The level of AFP can be meaningful during pregnancy. An AFP test is usually done between 16 and 18 weeks of gestation. The timing of this test is important and should be done in correlation to the gestational age of pregnancy and to the mother's weight. An elevated level of AFP can indicate problems with the fetus such as spina bifida (spinal cord problem) or conversely anencephaly (central nervous system defects) found in association between low levels of AFP. Low levels of AFP have also been linked with Down syndrome. In the past amniocentesis was the only way to test for Down syndrome. If the level of AFP is not normal, a detailed ultrasound examination is done to look for spina bifida, Down syndrome and anencephaly. This ultrasound may help determine how far you are into your pregnancy. AFP test is not done on all women. There risk involved is low and it basically informs your doctor on fetal growth and development.